Cheesy Chicken Butternut Squash Casserole Recipe

There’s nothing cozier on a chilly day than this chicken butternut squash casserole! 

It’s got layers of lean chicken, tender squash and aged Gruyere cheese, all topped with a golden brown crust that’ll knock your socks off. It’s truly comfort food at its best. 

We’re using whole, simple ingredients in this casserole that complement each other perfectly in flavor and texture.

And since it’s all made in one dish, it has become a favorite recipe in our house for busy weeknights. 

Ingredients for this Chicken and Squash Casserole

Here’s what you’ll need to make this easy dinner recipe: 

• Boneless skinless chicken breasts
• Butternut squash
• Gruyere cheese
• Onions
• Cream cheese
• Parmesan cheese
• Sour cream 
• Fresh sage
• Fresh thyme
• Egg
• Butter

How to Make this Casserole

Making this casserole is too easy! Grab a large bowl and put in the softened cream cheese, sour cream, Parmesan, egg and fresh herbs. Stir them together until the mixture is relatively smooth.

Now, fold the chicken, onions and squash into the cream cheese mixture. 

Then, transfer the whole thing to a 9×13 casserole dish. Top the casserole with cubes of Gruyere cheese. 

To make the bread crumb topping, simply combine the panko breadcrumbs with melted butter. Sprinkle it over top of the casserole and bake. 

Watch how to make Chicken Butternut Squash Casserole!

Serving Suggestions

This creamy chicken and squash casserole is a hearty main dish all on its own. Round out the meal with a lightly dressed salad and loaf of crusty bread. 

The recipe will feed 10-12 people as a main course, so if you want to half the recipe for a smaller group, simply use an 8×8 baking dish instead of a 9×13. 

Variations on this Chicken and Squash Casserole Recipe

1. The chicken: Boneless skinless chicken thighs can be used instead of breasts if you prefer. 

2. The cheese: Experiment with your favorite aged cheeses like sharp cheddar cheese or aged (not smoked) gouda cheese. 

3. The squash: Customize this chicken and squash recipe to fit the season! Try acorn squash or sugar pumpkin in the cooler months. In the warm months, try a summer squash like zucchini or yellow squash. 

Make Ahead and Storage

This is a great recipe to meal prep ahead of time.

Simply assemble the casserole and cover it tightly with one or two layers of plastic wrap, then another one or two layers of aluminum foil. Freeze it for up to 6 months in either a casserole dish or a disposable aluminum tin. 

When you are ready to bake your chicken and squash casserole, let it thaw in the refrigerator and bake according to the instructions in the recipe card.

If you are baking from frozen, adjust the cooking times accordingly. 

To store any leftover chicken and squash casserole, transfer leftovers to an airtight container and refrigerate. Leftovers will stay fresh for 5-7 days. 

When you make this chicken butternut squash casserole, I’d love to hear about it! Drop a rating or leave a comment below. Enjoy! 

For more casserole recipes, try these:

• Easy BBQ Chicken Casserole Recipe with Rice
• Tater Tot Casserole with Ground Turkey
• Easy Taco Bake Recipe