In a large stock pot over medium heat, brown the turkey. Season to taste with salt, pepper, garlic powder and onion powder as it cooks. Sprinkle with 1 Tbsp. of the Worcestershire sauce. Remove from the pot.
Add onions and peppers and saute until soft. Add the minced garlic. Season again with salt and pepper and cook until onion is translucent. Add the remaining worcestershire sauce, the spices and browned turkey to the pot, stirring to combine well.
Stir in the tomatoes, beans and masa flour. Simmer on low heat for 20-30 minutes and up to several hours.